|
KMID : 0358419960390081533
|
|
Korean Journal of Obstetrics and Gynecology
1996 Volume.39 No. 8 p.1533 ~ p.1542
|
|
|
Expression of Macrophage Colony-Stimulating Factor, Granulocyte Macrophage Colony-Stimulating Factor and Their Receptors in Ovarian Malignancies
|
|
류기성
한구택/류부학/박혜정/제동성/남궁성은/송승규/이헌영/김수평
|
|
|
Abstract
|
|
|
Colony-stimulating factors(CSFs) are a family of glycoprotein that are involved in the survival, proliferation, differentiation and activation of hematopoietic cells at various stage of their development. The clinical ramification and therapeutic
evaluation of hematopoietic growth factors are a rapidly growing field that holds promise for the treatment of various medical illness.
Many nonhematopoietic tumors produce hematopoietic growth factors that may influence cellular proliferation either by autocrine or by paracrine mechanism. So hematopoietic growth factors have been implicated in protean in protean nonhematopoietic
process.
In this study, expression of macrophage colony-stimulating factor(M-CSF), M-CSF receptor(M-CSF-R), granulocyte macrophage CSF(GM-CSF) and GM-CSF receptor(GM-CSFR) was investigated in 37 gynecologic tissues including 31 samples of malignant
ovarian
tumor
and 6 samples of benign ovarian tumor by RNA dot blot method. We systematically examined the relationship between the expression of CSFs and their receptors and clinical disease status.
@ES The results were as follows:
@EN 1. In 31 ovarian malignancies, RNA expression of CSFs and their receptors was detected from 15 cases(48.4%) in M-CSF, 20(64.5%) in M-CSF-R, 13(41.9%) in GM-CSF-R, Co-expression of M-CSF-R was found in 13 cases(41.9%) and that of GM-CSF and
GM-CSF-R
in 10 cases(30.3%). In 6 benign ovarian cysts, GM-CSF and GM-CSF-R expression were not detected, but M-CSF-R expression were detected in one case, even though at very low intensity.
2. CA 125, the most significant tumor marker in ovarian cancer, was significantly elevated in the groups that expressed the M-CSF(p=0.045), but not in M-CSF-R and GM-CSF-R.
3. There were significantly high rates of RNA expression of M-CSF, M-CSF-R, GM-CSF and GM-CSF-R in poorly differentiated tumors(grade 3) compared with well and moderately differentiated tumors(p=0.001, p=0.035, p=0.005, respectively), By means
of
Mantel-Haenszel Chi square analysis, the intensity of RNA expression also showed significant orrelation with the histologic grades in M-CSF(p=0.041).
4. Age of patient, tumor size, pathologic diagnosis and FIGO stage did not show any significant relation with te expression of CSFs and their receptors.
This results indicate that hematopoietic growth factor modulate tumorigenesis by autocrine and paracrine mechanisms and the expression of hematopoietic growth factor and its receptor in ovarian malignancies could contribute to their proliferative
and
invasive characteristics in vivo.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
  
|
|